About InoCardia
We are a UK-based, specialist provider of cardiotoxicity assessment services for Pharma & Biotech customers - In fact, we cover more of pharma research than any other provider*.
InoCardia brings superior, predictive, Award-Winning cardio-toxicity assays to pharmaceutical R&D.
Our technologies have received multiple grant awards. We recently completed (i) a 3-year, NC3R/InnovateUK project to miniaturise our Work Loop platform, (ii) An EIT Digital supported consortium to develop the first in silico/AI product able to identify cardiac contractility - 'The Contractome' and (iii) a project to assess cardiotoxicity in potential COVID-19 antivirals.
*InoCardia is the only provider offering predictive cardiotoxicity assessment through Design, Hit, Lead, Candidate Nomination and Regulatory stages of Pharma R&D.
Work Loop
Work Loop models are considered the gold standard of in vitro inotropy measurement. We manipulate pre- and after-load whilst simultaneously measuring the microscopic forces generated in heart muscles and myocytes. The Work Loop model can be considered as an in vitro version of the pressure volume loop.
Work Loop is diagnostic of both contractility and excitation coupling abnormalities and can provide insight into a drug's mode of action.
Work Loop has been characterised against over 70 cardiotoxic mechanisms and drugs.
For rapid ordering & delivery vist InoCardia at the Scientist.com online marketplace
CardioToxome
CardioToxome offers the earliest possible opportunity to identify cardiotoxicity currently available given no physical sample is required.
Built entirely from human clinical data, CardioToxome is an innovative new Safety Pharmacology concept that dramatically reduces the cost & time required to assess new drugs and is as predictive as in vitro ion-channel & cardiac safety panels combined.
CardioToxome studies can be ordered directly from Scientist.com or by contacting us below.
CardioToxome builds on our 'Contractome-AI' breakthrough product developed in collaboration with Cresset BioMolecules, UCB Pharma and Coventry University, and supported by EIT Digital (Horizon 2020), taking it to a new level. Fact Sheet@EITDigital
For Rapid Ordering & Delivery visit InoCardia at the Scientist.com online marketplace
Regulatory & Bespoke Studies
Our scientific team have wide expertise and knowledge in the safety pharmacology field. We offer the Langendorff model, a well studied and characterised model accepted by regulators and researchers alike.
We offer a more cost-effective alternative than your current provider, please contact us for a quote.
Need to find out more about your experimental drugs? Want to link your in vitro results to possible inotropy mechanism? Want to screen compound library exemplars for cardiotox when you dont have enough sample? Need a bespoke assay developing?
Then get in touch with us.
For Rapid Ordering & Delivery visit InoCardia at the Scientist.com online marketplace
18 - 03 - 2023
InoCardia wins 2023 MediLink Midlands 'One-To-Watch' Award